acme

Carboxyl Polystyrene Microspheres

Carboxyl Microspheres

Our high degree of specialization and expertise in microparticle technology enabled us to concentrate on all aspects of carboxyl microspheres. An enormous amount of research work has been focused on the development of every possible carboxyl microsphere for diagnostic assays. Within each size, we offer different levels of functionality to provide a range of selectivity, sensitivity, and specificity as desired for each application.

· More than 100 products - various sizes and surface charge densities

· Optimized levels of carboxyl and sulfate groups for maximum coupling efficiency

· Very uniform surface morphology and even distribution of functional groups

· Can be used without precleaning for most applications

· Highly uniform, stable, and reproducible

· Fluorescent and Dyed microspheres: Available in selected sizes

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
C020-50	20	270	175.7
C033-50	33	320	89.8
C042-50	42	200	112.9
C050-50	50	260	73.0
C052-50	52	230	79.3
C062-50	62	200	76.5
C071-50	71	120	111.3
C081-50	81	140	83.6
C094-50	94	130	77.6
C097-50	97	100	97.8
C098-50	98	115	84.2
C100-50	100	170	55.8
C104-50	104	110	82.9
C105-50	105	110	82.1
C115-50	115	110	75.0
C120-50	120	180	43.9
C127-50	127	120	62.2
C130-50	130	170	42.9
C135-50	135	200	35.1
C136-50	136	90	77.5
C136B-50	136	170	41.0
C140-50	140	170	39.9
C146-50	146	105	61.9
C160-50	160	65	91.2
C172-50	172	160	34.5
C193-50	193	190	25.9
C195-50	195	65	74.8
C201-50	201	165	28.6
C206-50	206	115	40.0
C207-50	207	170	27.0
C210-50	210	80	56.5
C213-50	213	116	27.8
C226-50	226	85	49.4
C230-50	230	125	33.0
C258-50	258	110	33.4
C267-50	267	110	32.3
C286-50	286	90	36.9
C297-50	297	100	31.9
C300-50	300	70	45.2
C309-50	309	70	43.9
C313-50	313	100	30.3
C358-50	358	60	44.2
C376-50	376	80	31.5
C394-50	394	70	34.4
C408-50	408	60	38.7
C419-50	419	110	20.6
C491-50	491	55	35.1
C600-50	600	110	14.4
C614-50	614	70	22.1
C840-50	840	70	16.1
C930-50	930	100	10.2
C1020-50	1020	70	13.3
C1120-50	1120	60	14.1
C1730-50	1730	25	21.9

Near soap free Carboxyl Microspheres

ACME innovative process technology has led to the development of a novel product line, “Near-Soap-Free” carboxyl microspheres with high MW. The surface chemistry is similar to conventional microspheres, very uniform and stable, but with very little surfactants.

· Better than soap-free microparticles with no residual monomer and with optimum amount of sulfate groups

· The very little surfactant level with a novel process technology provides stability and uniformity throughout the polymerization

· Surfactant levels of the products are very low (from 0.01% to 0.05%) and do not require clean up

· Optimized levels of carboxyl groups and uniform surface morphology for maximum coupling efficiency

· Highly uniform, stable, and reproducible

· Fluorescent and Dyed microspheres: Available in selected sizes

· We also make it to your exact specs

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
NC120-50	120	200	39.5
NC135-50	135	220	31.9
NC195-50	195	200	24.3
NC207-50	207	185	24.8
NC300-50	300	110	28.7
NC315-50	315	100	30.1
NC380-50	380	80	31.2
NC420-50	420	110	20.5
NC600-50	600	110	14.4

Space-Link Carboxyl Microspheres

Space-Link Carboxyl Microspheres are perfect immunodiagnostic reagent particles with a spacer-linker already attached to the microspheres. The length of the flexible spacer arm is ~10A°. The end of the spacer arm has a carboxyl group for covalent attachment of ligands. The second generation of SpaceLink microspheres have been developed and tested at ß-sites for best coupling efficiency.

The benefits of Space-Link Carboxyl microspheres include:

· Almost all of the ligands coupled to the microspheres will be in an active form

· Conformational changes or orientation problems of the ligands are minimized when the ligands are located away from the surface of the particles

· Higher level of sensitivity compared to direct surface coupling; Lesser amount of ligand needed to get the required sensitivity

· The flexible spacer arms improve the kinetics of agglutination reactions and reactivity of each coupled ligand by keeping the ligands away from the surface of the particles

· Antigen/antibody recognition sites line up much more easily

· The flexible spacer arms greatly reduce steric hindrance problems

· We also make it to your exact specs

· Also available: Space-Link Hydroxyl microspheres

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
SC095-50	95	60	166.4
SC107-50	107	90	98.5
SC175-50	175	60	90.3
SC200-50	200	55	86.2
SC240-50	240	55	71.9
SC280-50	280	45	75.3
SC300-50	300	45	70.3
SC382-50	382	40	62.1
SC591-50	591	40	40.1
SC1010-50	1010	35	26.8

Specialty Carboxyl with steric effects

These microspheres are designed with bulky groups to minimize passive adsorption and reduce non-specific binding.

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
SCS165-50	165	160	35.9
SCS296-50	296	90	35.6
SCS310-50	310	82	37.3

Hydrophilic Carboxyl microspheres

These microspheres are designed to enhance stability and reactivity.

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
HC100-50	100	230	41.2
HC182-50	182	145	35.9
HC200-50	200	170	27.9
HC300-50	300	90	35.1

Lipophilic Carboxyl Microspheres

Our innovative process technology and formulations have led to the development of novel lipophilic (lipid incorporated/coated) carboxyl microspheres. These microspheres have been developed with optimized levels of different lipids to increase the coupling efficiency of various proteins.

· The lipophilic microspheres contour to the conformation of the proteins for better coupling efficiency and improved visibility of the agglutinates

· We also make it to your exact specs

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
OL213-50	213	90	49.5
OL242-50	242	90	43.6
OL308-50	308	115	26.8

Low-Density Carboxyl Microspheres

Our innovative process technology and formulations have led to the development of novel low-density carboxyl microspheres.

· Optimized levels of carboxyl and sulfate groups for maximum coupling efficiency

· Highly uniform, stable, and reproducible

· Designed to reduce settling

Catalog Number	Diameter, nm	Density	Carboxyl µEquiv/gram	Parking Area

LC106-50	106	1.03	130	68.8
LC129-50	129	1.02	202	36.4
LC153-50	153	1.02	130	47.7
LC298-50	298	1.03	80	39.8
LC302-50	302	1.02	80	39.3
LC306-50	306	1.02	80	38.7
LC310-50	310	1.01	82	37.3
LC388-50	388	1.02	120	20.4
LC407-50	407	1.02	110	21.2
LC421-50	421	1.02	75	30.0
LC489-50	489	1.02	124	15.6
LC1117-50	1117	1.035	59	14.4
LC1730-50	1730	1.035	26	21.1

Non-polystyrene Carboxyl microspheres

These microspheres are designed to reduce non-specific binding and are easy to centrifuge.

Catalog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
NPC098-50	98	105	92.2
NPC168-50	168	164	34.4
NPC194-50	194	148	33.0
NPC298-50	298	72	44.2
NPC402-50	402	62	38.1

High-Density Carboxyl Microspheres

Diameter, nm	Catalog Number	Density	Carboxyl µEquiv/gram	Parking Area
100	HDC100-50	1.19	102	93.0
170	HDC170-50	1.19	160	34.9
200	HDC200-50	1.19	150	31.6
300	HDC300-50	1.19	70	45.2
400	HDC400-50	1.19	60	39.5

Soap-Free Carboxyl Microspheres

Our distinctive soap-free carboxyl microspheres have the following unique features:

· Optimum sulfate and carboxyl groups to stabilize the microparticles

· Innovative process technology and formulation provide stability and uniformity throughout the polymerization

· Optimized levels of carboxyl groups and uniform surface morphology for maximum coupling efficiency. No excess sulfate groups to interfere with coupling chemistry.

· No residual monomer

· Very uniform, stable, and reproducible

· Fluorescent and Dyed microspheres: Available in selected sizes

· We also make it to your exact specs

Catolog Number	Diameter, nm	Carboxyl µEquiv/gram	Parking Area
SFC100-50	100	170	55.8
SFC120-50	120	180	43.9
SFC135-50	135	200	35.1
SFC146-50	146	105	61.9
SFC172-50	172	160	34.5
SFC195-50	195	200	24.3
SFC202-50	202	165	28.5
SFC300-50	300	110	28.7
SFC380-50	380	80	31.2
SFC600-50	600	110	14.4

Fluorescent / Dyed Carboxyl Microspheres

Standard Colors: Fluorescent Yellow, Blue, Red, Hot Pink, Pink, Violet, Coral, Lavender, and other colors

We can custom dye any product in this catalog to the color of your choice.